KTP Associate (PDRA) in Peptide Therapeutics in collaboration with Bicycle Therapeutics

£36024 - £44263

Cambridge, Cambridgeshire - 30 months

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Job description

A unique opportunity for a successful applicant to undertake research at the intersection of academia and industry to develop novel imaging technologies using bicyclic peptides. The UKRI Innovate UK funded Knowledge Transfer Partnership (KTP) is a collaboration between Cambridge University and Bicycle Therapeutics (BicycleTx).

Based at BicycleTx, Cambridge UK, in collaboration with the Spring Group at the University of Cambridge, the successful applicant will contribute to achieve the KTP’s objectives to develop and transfer knowledge as well as techniques required to develop new imaging technologies.

The KTP Associate will be an employee of the University of Cambridge but will spend most of their working time at BicycleTx`s premises at Granta Park, Great Abington, Cambridge, CB21 6GS and when required at the University of Cambridge. The contract is a fixed term for a duration of 30 months.

Knowledge, Skills and Experience
• Profound knowledge in pharmaceutical sciences
• Extensive experience in peptide chemistry and particularly of bicyclic peptide chemistry (design, synthesis, purification and analysis)
• Experience in protein biochemistry and cell biology
• Experience in a wide range of biochemical and biophysical techniques
• Be driven, demonstrate creative thinking, showcase evidence of scientific leadership, be a strong team player with an ability to work alone and take ownership of a project as well as deliver key objectives as part of a team, be flexible and adapt to changes in the project and demonstrate excellent communication skills both oral and written (essential)
• Proficiency in bicyclic peptide construction and structure activity relationships for early lead optimisation (desirable)
• Industrial work experience (desirable)
Attributes and Behaviour
• Passion for drug discovery, particularly interested in the challenges of bicyclic peptide chemistry
• Ability to be flexible across chemical and biological methods and technologies
• Adapt to changes in the project
• Exceptionally driven and motivated
• Excellent organisational and planning skills
• Thrives in a project environment with ability to work to tight deadlines
• The ability to work independently and collaboratively
• Strong interpersonal skills with the ability to communicate at all levels to different stakeholder groups in both academia and industry
• Good attention to detail
• Is a natural problem solver

Project description

A unique opportunity for a successful applicant to undertake research at the intersection of academia and industry to develop novel imaging technologies using bicyclic peptides. The UKRI Innovate UK funded Knowledge Transfer Partnership (KTP) is a collaboration between Cambridge University and Bicycle Therapeutics (BicycleTx).

Based at BicycleTx, Cambridge UK, in collaboration with the Spring Group at the University of Cambridge, the successful applicant will contribute to achieve the KTP’s objectives to develop and transfer knowledge as well as techniques required to develop new imaging technologies.

The KTP Associate will be an employee of the University of Cambridge but will spend most of their working time at BicycleTx`s premises at Granta Park, Great Abington, Cambridge, CB21 6GS and when required at the University of Cambridge. The contract is a fixed term for a duration of 30 months.

About the business

Bicycle Therapeutics was founded in 2009 to develop a novel therapeutic modality based on Bicycles and to develop these as transformative medicines targeting diseases with high therapeutic needs.

Pharma

Pharmaceutical

Qualifications PhD (or final stages of completion) in Chemistry, Biochemistry or closely related field Key Tasks • On boarding, familiarisation with the company and university • Creation of a detailed plan and complete a mini project • Design, synthesis, purification and analysis of chemically modified bicyclic peptides • Phage display using BicycleTx’s proprietary technology • Assay development and implementation • Determination of pharmacokinetic parameters • Disseminate and embed developed knowledge within BicycleTx to various stakeholders throughout the KTP via reports, presentations, group discussions, workshops and staff training • Present findings to stakeholders prepare and complete full documentation • Disseminate research via scientific publications and conferences

27 November 2023

1 March 2027

1 March 2024

Camb Bicycle Tx


A unique opportunity for a successful applicant to undertake research at the intersection of academia and industry to develop novel imaging technologies using bicyclic peptides. The UKRI Innovate UK funded Knowledge Transfer Partnership (KTP) is a collaboration between Cambridge University and Bicycle Therapeutics (BicycleTx).

Based at BicycleTx, Cambridge UK, in collaboration with the Spring Group at the University of Cambridge, the successful applicant will contribute to achieve the KTP’s objectives to develop and transfer knowledge as well as techniques required to develop new imaging technologies.

The KTP Associate will be an employee of the University of Cambridge but will spend most of their working time at BicycleTx`s premises at Granta Park, Great Abington, Cambridge, CB21 6GS and when required at the University of Cambridge. The contract is a fixed term for a duration of 30 months.

Knowledge, Skills and Experience
• Profound knowledge in pharmaceutical sciences
• Extensive experience in peptide chemistry and particularly of bicyclic peptide chemistry (design, synthesis, purification and analysis)
• Experience in protein biochemistry and cell biology
• Experience in a wide range of biochemical and biophysical techniques
• Be driven, demonstrate creative thinking, showcase evidence of scientific leadership, be a strong team player with an ability to work alone and take ownership of a project as well as deliver key objectives as part of a team, be flexible and adapt to changes in the project and demonstrate excellent communication skills both oral and written (essential)
• Proficiency in bicyclic peptide construction and structure activity relationships for early lead optimisation (desirable)
• Industrial work experience (desirable)
Attributes and Behaviour
• Passion for drug discovery, particularly interested in the challenges of bicyclic peptide chemistry
• Ability to be flexible across chemical and biological methods and technologies
• Adapt to changes in the project
• Exceptionally driven and motivated
• Excellent organisational and planning skills
• Thrives in a project environment with ability to work to tight deadlines
• The ability to work independently and collaboratively
• Strong interpersonal skills with the ability to communicate at all levels to different stakeholder groups in both academia and industry
• Good attention to detail
• Is a natural problem solver